Franklin HAD-3007 Manuel utilisateur



HAD-3007

Medical Book Card

User’s Guide



MBS

Medical Book System™

The Medical Letter

HANDBOOK

ADVERSE

DRUG

INTERACTIONS

Quick Reference Guide

To Start Using a Book Card

1. Install the book card in a slot in the

back of the Medical Book System

platform.

2. Turn the platform on.

3. If needed, press

CARD

and then

use the or to highlight its

icon.

4. Press

ENTER

to select it.

To Find Drug Interactions

Press

CLEAR

2. Highlight a drug by typing its name

or pressing or and then press

ENTER

to select it.

3. Select more drugs by highlighting

them and pressing

ENTER

4. Press

5. Highlight an interaction, if any, and

press

ENTER

to view it.

To Find All Other Drug Interactions

Press

CLEAR

2. Highlight a drug by typing its name

or pressing or and then press

ENTER

to select it.

3. If needed, select more drugs by

highlighting them and pressing

ENTER

4. Press

5. Highlight an interaction, if any, and

press

ENTER

to view it.

To Find a Glossary Entry

Press

CLEAR

2. Highlight a drug by typing its name

or pressing or .

3. Press

SPEC

4. Use ,

, or

SPACE

to scroll.

5. Press

BACK

to go back.

READ THIS LICENSE AGREEMENT BEFORE USING THE MEDICAL BOOK

SYSTEM.

YOUR USE OF THE MEDICAL BOOK SYSTEM DEEMS THATYOU ACCEPT

THE TERMS OF THIS LICENSE. IF YOU DO NOT AGREE WITH THESE

TERMS, YOU MAY RETURN THIS PACKAGE WITH PURCHASE RECEIPT TO

THE DEALER FROM WHICH YOU PURCHASED THE MEDICAL BOOK SYS-

TEMAND YOUR PURCHASE PRICE WILL BE REFUNDED. The MEDICAL

BOOK SYSTEM means the software product, hardware, and documentation found in

this package and FRANKLIN means Franklin Electronic Publishers, Inc.

LIMITED USE LICENSE

All rights in the MEDICAL BOOK SYSTEM remain the property of FRANKLIN.

Through your purchase, FRANKLIN grants you a personal and nonexclusive license to

use the MEDICAL BOOK SYSTEM. You may not make any copies of the MEDICAL

BOOK SYSTEM or of the preprogrammed data stored therein, whether in electronic or

print format. Such copying would be in violation of applicable copyright laws. Further,

you may not modify, adapt, disassemble, decompile, translate, create derivative works

of, or in any way reverse engineer the MEDICAL BOOK SYSTEM. You may not ex-

port or re-export, directly or indirectly, the MEDICAL BOOK SYSTEM without com-

pliance with appropriate governmental regulations. The MEDICAL BOOK SYSTEM

contains Franklin’s confidential and proprietary information which you agree to take

adequate steps to protect from unauthorized disclosure or use. This license is effective

until terminated. This license terminates immediately without notice from FRANKLIN

if you fail to comply with any provision of this license.

License Agreement

Contents

➤

About Book Card Compatibility

IMPORTANT This book card can be

used only with the Medical Book Sys-

tem

™

platform and will not function in any

other Franklin BOOKMAN

platform.

The Medical Book System platform

can use Franklin BOOKMAN book

cards as well as Medical Book System

book cards. However, Franklin BOOK-

MAN platforms cannot use Medical

Book System book cards.

➤

For More Information

To learn more about the Medical Book

System or other products from Frank-

lin Electronic Publishers, call 800-665-

5450 or visit the Franklin Web site at

www.franklin.com.

Key Guide..................................... 4

Installing Book Cards .................. 5

Selecting a Book .......................... 6

Changing the Settings ................. 6

Viewing a Demonstration ............ 7

Finding Drug Interactions ........... 7

For a Single Drug ........................... 7

Among Many Drugs ....................... 8

Using the Interactions Menu ..... 10

Using the Glossary .................... 11

Highlighting Search Words ....... 11

Reading Special Markers........... 12

Looking Up Words

in Other Books ........................... 13

Resetting the Medical

Book System .............................. 13

Book Card Care.......................... 14

Specifications and Patents ....... 14

Limited Warranty (U.S. only) ..... 15

Index ........................................... 16

Introduction to the HADI

This handbook offers a quick guide to pos-

sible adverse effects of drug interactions,

with brief recommendations for precaution-

ary measures. Pairs of interacting drugs are

listed alphabetically, followed by the ad-

verse interaction, its mechanism (in paren-

theses), references and recommendations

for clinical management. These listings are

usually based on clinical reports. Interac-

tions listed for groups of drugs (such as

“cephalosporins” or “antidepressants, tricy-

clic”) may not have been reported for every

drug in the group; known exceptions to the

interaction are noted.

It is not possible to determine the frequency of

most interactions. When an interaction is docu-

mented by one or two case reports rather than

clinical studies or reports in many patients, the

year of each report is given as some indication

of frequency.

Reports of interactions between more than two

drugs have begun to appear in the medical lit-

erature. Where these have been documented,

they are noted as comments under interacting

pairs of drugs.

UNDOCUMENTED INTERACTIONS ––

New adverse interactions are continually being

reported; the absence of a listing in this book

does not necessarily mean that drugs will not

interact when given concurrently. Interactions

extrapolated from animal studies or interac-

tions reported with related drugs, frequently

mentioned in other sources, such as the

manufacturer’s package insert may not be in-

cluded here.

Interactions between general anesthetics and

drugs likely to be administered during surgery,

such as autonomic drugs and local anesthetics,

are not included. Interactions useful in therapy,

such as increased plasma concentration of

penicillin with concurrent use of probenecid,

are also not listed. Drug combinations should

be looked up under their components.

Common additive effects, such as occur with

use of two antihypertensive agents or two cen-

tral nervous system depressants, are generally

not listed. Effects expected from the mechanism

of a drug’s action, such as that of potassium on

digitalis glycosides or calcium on calcium-entry

blockers, and useful antagonist effects, such as

that between a poison and an antidote, are also

not included. Most interactions of drugs with

foods, beverages, or other nutrients are not

listed, but foods interacting with monoamine

oxidase inhibitors are included.

MECHANISMS OF INTERACTIONS —

Genetic differences can affect drug metabolism

and interactions. Some drugs can interact by

changing the metabolism of other drugs, either

through inhibition or induction of any of sev-

eral hepatic enzyme activities or through alter-

ations in hepatic blood flow. Many drugs are

metabolized by cytochrome P450 isozymes.

These isozymes are named according to a stan-

dard system, e.g., CYP3A4 or P4503A4.

Drugs that are substrates or inhibitors for the

same isozyme in vitro are likely to interact, but

no interaction may be detectable, or it may not

be clinically significant. Other drugs alter the

binding of another drug to plasma proteins or

tissue receptors, alter the distribution of drugs

to active receptor sites, delay or enhance excre-

tion, or cause additive or synergistic effects.

RECOMMENDATIONS — Monitoring is

most important when one of the interacting

drugs is stopped or started. Some experienced

clinicians may prefer to monitor the patient’s

clinical status rather than follow serum concen-

trations of drugs. Concurrent use of drugs from

the same group, e.g., aspirin and other

NSAIDs, should be avoided.

Introduction to the HADI Key Guide

Color Keys

(red)Displays interactions between

selected drug(s) and all other drugs

in this book.

SPEC

(green)Displays a glossary entry.

(yellow)Searches for interactions

among the selected drugs.

LIST

(blue) Lists the items currently se-

lected from the main drug list.

Function Keys

BACK

Erases typed letters, or backs up to

the previous screen.

CAP

Shiftskeystotypecapitalsorpunctuation.

CARD

Exits the currently selected book.

CLEAR

Clears your search and returns to

the main drug list.

ENTER

Enters a word, selects a menu item,

or starts the highlight in text.

HELP

Displays help messages.

Displays the main menus.

ON/OFF

Turns the platform on or off.

SPACE

At menus and text, pages down. At

entry screens, types a space.

✻

At menus, displays the title of a high-

lighted item.At text, displays the current

entry title. With

CAP

, types an asterisk

(✽) to stand for letters in a word.

Key Guide

Direction Keys

Pages up or down.

Moves the cursor, text, or highlight.

Key Combinations*

✩

CARD

Transfers a highlighted word

between installed book cards.

✩

ENTER

At text, highlights special mark-

ers (e.g., bibliographic

references, MAO inhibitor in-

formation , etc.).

✩

+Q-P Types numbers.

✩

At text, displays the next or

previous interaction or search

match.

CAP

Goes to the top or bottom of

a menu or text.

➤

Understanding the Keys

The functions of the keys may vary ac-

cording to which book card is installed

and selected in the platform. To learn

how to use a particular book card, read

its User’s Guide.

* Hold the first key while pressing the second.

CAUTION Never install or remove a

book card when the platform is turned on.

If you do, information entered in any

installed book cards may be erased.

1. Turn the platform off.

2. Turn the platform over.

3. Align the book card tabs with the

notches in a card slot.

4. Press the book card until it snaps

into the slot.

Installing Book Cards

➤

Removing Book Cards

CAUTION When you remove a book

card from a platform, information en-

tered in that book card may be erased.

If you have installed two book cards in

the platform, you can select which book

you want to read.

1. Turn the platform on.

2. Press

CARD

3. Use or to highlight the book

you want to use.

4. Press

ENTER

to select it.

Selecting a Book

➤

Resuming Where You Left Off

You can turn off the platform at any

screen. When you turn it on again, the

last screen that you viewed appears.

Changing the Settings

Using the Setup menu, you can adjust the

type size, shutoff time, and screen contrast of

this book.

The type size sets how large the charac-

ters appear on screen. The shutoff time

sets how long your Medical Book System

stays on if you forget to turn it off.

1. Press

2. Highlight

Set Type Size, Set Shutoff

Set Contrast

on the Setup menu.

3. Press

ENTER

4. Use or to change the setting.

Or press

BACK

to leave the setting

unchanged.

5. Press

ENTER

to select it.

Before you start using this book, you may

want to see a brief demonstration.

Press

and then use the arrow keys to

highlight View Demo on the Setup menu.

Press

ENTER

to select it. To stop the dem-

onstration, press

CLEAR

Viewing a Demonstration

Finding Drug Interactions

For a Single Drug

You can select a single drug from the

main drug list and quickly find drugs with

which it interacts.

1. Press

CLEAR

2. Type a drug name. For example,

type

heparin

To delete a letter, press

BACK

You can also highlight a menu item by

using or .

To type a number, hold

✩

and press a

numbered key.

To see a full menu title, press

? ✻

3. When the drug is highlighted, press

ENTER

to select it.

A check marks your selection.

To deselect a drug, press

ENTER

again.

4. Press

(red) to find all the in-

teractions for the selected drug

listed in this book.

➤

Help is Always at Hand

You can view a help message at virtu-

ally any screen by pressing

HELP

. To

exit help, press

BACK

To read a tutorial about this book, se-

lect Tutorial from the Setup menu.

For more information about the Hand-

book of Adverse Drug Interactions, se-

lect Introduction from the Setup menu.

➤

Follow the Arrows

The flashing arrows at the right of the

screen show which arrow keys you can

press to move through menus or view

more text.

These are the interactions for heparin.

5. Type an interaction title or use the

arrow keys to highlight an interac-

tion. For example, highlight

heparin

& nitroglycerin

6. Press

ENTER

to view it.

To go to the next or previous interac-

tion, if any, hold

✩

and use

8. Press

CLEAR

when finished.

Finding Drug Interactions

Among Many Drugs

You can select up to 20 drugs at a time

and find their interactions.

1. Press

CLEAR

2. Select a drug from the main drug

list. For example, select

quinine

A check marks your selection.

3. Select another drug. For example,

select

acetaminophen

To deselect a drug, press

ENTER

again.

You can add more drugs here if you wish.

To see the drugs you have selected,

press

LIST

(blue).

To see the glossary entry of a drug on

your query list, highlight it and press

SPEC

(green) or

ENTER

Finding Drug Interactions

➤

About the Main Drug List

The main drug list contains brand and ge-

neric drugs, foods, as well as drug and

food groups. Brand names are capital-

ized, but you do not need to type capitals.

Note: In this User’s Guide, “drug” re-

fers to any item on the main drug list.

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