Fluidic Analytics Fluidity One Manuel utilisateur

IFU 004 User Guide Issue 4

Fluidic Analytics products have been designed to be safe in accordance with the operating instructions. If the equipment is not

used in the manner specified in the operating manual the equipment may be impaired and warranty may be void, warranty

exclusions include:

•Defects caused by improper operation or opening of the manifold.

•Repair or modification done by anyone other than Fluidic Analytics or an authorized agent.

•Damage caused by accident or misuse.

•Damage caused by disaster.

•Corrosion due to use of improper sample.

The information contained in this manual is subject to change without notice. Fluidic Analytics shall not be liable for errors

contained herein or for incidental or consequential damages in connection with the performance, or use of this material. This

document contains information that is protected by copyright. All rights are reserved. No part of this document may be

photocopied, reproduced, or translated to another language without prior written consent of Fluidic Analytics.

Document reference: IFU004 Issue 4

General information ...................................................................................................................................3

Safety information .....................................................................................................................................4

2.1. Hazard summary ............................................................................................................................................. 5

2.2. Noise.................................................................................................................................................................... 5

2.3. Ventilation and air extraction ...................................................................................................................... 5

2.4. Chemical safety................................................................................................................................................ 6

2.5. Manual handling .............................................................................................................................................. 6

2.6. Power requirements....................................................................................................................................... 6

Instrument specifications..........................................................................................................................7

3.1. Fluidity One Instrument Purpose ............................................................................................................... 7

3.2. Chips ................................................................................................................................................................... 7

3.3. Reagent cartridge............................................................................................................................................ 8

User Training...............................................................................................................................................9

Installation ...................................................................................................................................................9

5.1. Dimensions and required operating space ............................................................................................. 9

5.2. Instrument location......................................................................................................................................... 9

5.3. Transportation and handling .....................................................................................................................10

5.4. Preparing the instrument............................................................................................................................10

5.5. Operating conditions....................................................................................................................................10

5.6. Connections ....................................................................................................................................................10

Operation .................................................................................................................................................. 12

6.1. Manual checks................................................................................................................................................12

6.2. Turning on and off ........................................................................................................................................12

6.3. Pipetting onto chips .....................................................................................................................................13

6.4. Loading chips .................................................................................................................................................13

6.5. Replacing reagent cartridges ....................................................................................................................14

6.6. Starting the measurement..........................................................................................................................15

6.7. Calibration .......................................................................................................................................................17

Instrument priming ................................................................................................................................. 17

Viewing Results....................................................................................................................................... 18

Shut down ................................................................................................................................................ 20

User Accounts.......................................................................................................................................... 20

Results storage and download............................................................................................................. 20

11.1. How to download results.......................................................................................................................20

11.2. File formats available for results download .....................................................................................21

Cleaning .................................................................................................................................................... 21

Service, Maintenance and Fault Repairs............................................................................................. 21

Decommissioning and storage ............................................................................................................. 21

Contacting customer support ............................................................................................................... 21

General information

This manual details the installation, maintenance and ownership of the Fluidity One

instrument produced by

Fluidic Analytics Limited

Unit A The Paddocks Business Centre

Cherry Hinton Road

Cambridge

CB1 8DH

This manual provides a guide for the installation and upkeep of the Fluidity One by trained

service personnel and users. All users must familiarise themselves with the safety guidelines

and general operation information sections of this manual prior to use.

The software described in this manual is version 2.2

Safety information

WEEE Directive (2012/19/EU)

For professional users in the European Union

If you wish to discard electrical and electronic equipment (EEE), please contact Fluidic

Analytics Ltd for further information.

The Fluidity One contains a Lithium Coin Cell Battery with the following warnings:

REACH Regulation (EC) No 1907/2006

Substances of Very High Concern (SVHC) Information

This product has been found to contain SVHC:

1,2-dimethoxyethane, ethylene glycol dimethyl ether (EGDME)

CAS number:

110-71-4

The product is compliant with the following directives (provided it is

used with the supplied peripheral components):

•The Radio Equipment Directive (2014/53/EU)

•Safety Testing EN 61010-1:2010

•EMC Testing EN 61326-1:

Warning: This is a Class A product. In a domestic environment this product may

cause radio interference in which case the user may be required to take adequate

measures.

•The Restriction of Hazardous Substances in Electronic Equipment Directive

(2011/65/EU) (RoHS)

2.1. Hazard summary

The following hazards are present on the Fluidity One instrument:

The operator must not remove any covers or open any electrical enclosures,

or power supply units, on or supplied with the machine. Lethal voltages are

present in these enclosures and the Fluidity One contains automatically

controlled moving mechanisms where there is a danger of fingers being

crushed

The Fluidity One uses an in built air compressor to control liquid movement

through the instrument.

The Fluidity One contains a UV light source. This does not present a danger

to users provided the unit is not opened.

The Fluidity One contains a fan. This does not present a danger to users

provided the unit is not opened.

2.2. Noise

Testing was carried out on the instrument to measure airborne noise emissions. No specific

precautions are required when using this instrument with regards to noise.

2.3. Ventilation and air extraction

If this instrument is being used with toxic chemicals that could pose a risk to the user

(should they come in contact with them or their vapours) the instrument should be operated

inside a suitable fume cupboard. Assessment of the risks of chemicals and reagents for use

with the instrument is the sole responsibility of the user. Compatibility of the user’s

chemicals with the Fluidity One is the responsibility of the user.

2.4. Chemical safety

Any toxic chemicals used with the Fluidity One instrument are the responsibility of the user.

Refer to the Materials Safety Data Sheet provided with the reagent cartridge for hazards

associated with the reagent cartridge (Reference: MSDS001)

2.5. Manual handling

The Fluidity One weighs 16 kg and should be carried with the appropriate level of care.

2.6. Power requirements

The power pack is usable from 100-240VAC, 50-60Hz. The unit requires an earth. Only use

the power lead supplied with the unit.

Instrument specifications

3.1. Fluidity One Instrument Purpose

The Fluidity One uses Microfluidic Diffusional Sizing to size and quantify unlabelled, native

protein in solution in less than 15 minutes. This can be used in a laboratory environment for

routine protein sizing, protein quality analysis, study of protein conformation, aggregation or

oligomerization and analysis of protein interactions.

3.2. Chips

Samples are loaded sequentially into the Fluidity One using disposable microfluidic chips.

The chips are made of Cyclic Olefin Copolymer (COC), manufactured using injection

moulding and include a loading pedestal for the pipetting of 5-10 µL of sample. The chip is

validated for single use.

Chips may be disposed of in a similar manner to other biohazardous laboratory waste.

3.3. Reagent cartridge

Reagent cartridges are supplied with colour coded connections and can be connected to the

Fluidity One instrument as shown.

Do not disconnect the reagent cartridge while an experiment is running.

Reagent cartridges are disposable and should not be re-filled by users.

For full instructions on changing a reagent cartridge, see section 6.5.

New cartridge

Blanking caps cover

each port and must be

removed before use.

Connection ports

Colour coded to match

the hoses in the

instrument.

Connected cartridge

The connectors at the

end of each hose click

onto the cartridge

ports.

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