Biotage®Flash 400 User Manual | © Biotage 2018
Description and Specifications
Description and Specifications
Figure 2
A
B
C
E
H
I
G
D
.Flash 400 system. A = hoist, B = hoist control box, C = cartridge
tool, D = prepacked cartridge, E = radial compression module, F = radial
compression fluid reservoir, G = control panel, H = solvent inlets and
fraction outlets, and I = air and nitrogen inlets.
Biotage®Flash Frame
The Flash 400 radial compression module is mounted on a
portable frame. The frame includes a side connection panel with
bulkhead compression fittings for connecting solvent reservoirs
(inlet A and B), collection vessels (outlet 1 and 2), a nitrogen
supply (radial compression fluid reservoir and module), and a
compressed air supply (solvent pump). The air supply for the
hoist is connected at the rear of the hoist. For more information
see “Installation” on page 14.
The system is fully plumbed and ready for installation.
Figure 14 on page 8 shows the overall dimensions.
Radial Compression Module
The Flash 400 radial compression module (see E in Figure 2)
is an ASME rated and CE marked pressure vessel. The barrel is
fabricated from 316L stainless steel while the top head, bottom
head, and clamps are machined from 316 stainless steel. The
interior and exterior surfaces have been mechanically polished.
The radial compression module is rated at 170 psig (11.7 bar)
maximum pressure. The system includes several pressure relief
valves to help ensure that the operating pressure does not
exceed this specification.
Note: The radial compression module’s polished surfaces must
be protected to minimize mechanical damage.
Additional Radial Compression Barrel
The system supports two interchangeable barrels for use with
either 400 mm x 300 mm (Flash 400M) or 400 mm x 600 mm
(Flash 400L) cartridges. One of the radial compression barrel
sizes is included in the system and the barrel of the other size
can be ordered.
O-Rings
The head assembly includes a two piece stainless steel
cartridge seal adapter with two Chemraz O-rings (A & B); see
5 and 6 in Figure 3. The cartridge seal adapter seals against
the seal adapter plate when the face O-ring (A) is compressed.
The radial O-ring (B) seals the adapter to the head.
The top and bottom head assemblies seal to a tapered surface
on the cartridge and to the radial compression barrel with either
Viton (as shipped) or EPDM (spares) O-rings (C & D); see 3 and 2
in Figure 3. These O-rings are non-product contact surfaces.
The Viton and EPDM O-rings are very compressible and will
seal reliably up to 100 psig (6.9 bar). EPDM is resistant to polar
solvents but will swell in many common aliphatic and aromatic
solvents. Viton is resistant to non-polar solvents, but will
swell in the typical polar modifiers. For solvent compatibility
information, see Table 1.
Table 1 only covers a limited number of commonly used
solvents. To check the compatibility of a particular solvent or
solvent mixture, soak an O-ring in the solvent/mixture for one
hour and then inspect it for swelling. If the O-ring swells in use,
allow it to dry out in a fume hood until it returns to its normal
size (typically overnight).
Inspect your O-rings before each run and replace any O-ring
that shows signs of wear or damage or that leaks at your typical
operating pressures. See Table 2 for part numbers and Figure 3
for location.
F
