Waters TQ Detector Manuel utilisateur

Waters TQ Detector

Quick Start Guide

71500126803/Revision A

OR PARTS THEREOF MAY NOT BE REPRODUCED IN ANY FORM

WITHOUT THE WRITTEN PERMISSION OF THE PUBLISHER.

The information in this document is subject to change without notice and

should not be construed as a commitment by Waters Corporation. Waters

Corporation assumes no responsibility for any errors that may appear in this

document. This document is believed to be complete and accurate at the time

of publication. In no event shall Waters Corporation be liable for incidental or

consequential damages in connection with, or arising from, its use.

Waters Corporation

34 Maple Street

Milford, MA 01757

USA

Trademarks

Connections Insight, ESCi, and Waters are registered trademarks of Waters

Corporation. ACQUITY UPLC, IntelliStart, IonSABRE, MassLynx, T-Wave,

UPLC, and ZSpray are trademarks of Waters Corporation.

Other trademarks or registered trademarks are the sole property of their

respective owners.

iii

Customer comments

Waters’ Technical Communications department invites you to tell us of any

errors you encounter in this document or to suggest ideas for otherwise

improving it. Please help us better understand what you expect from our

documentation so that we can continuously improve its accuracy and

usability.

We seriously consider every customer comment we receive. You can reach us

at tech_comm@waters.com.

Waters Corporation

34 Maple Street

Milford, MA 01757

USA

Safety considerations

Some reagents and samples used with Waters®instruments can pose

chemical, biological, and radiological hazards. Be sure you are aware of the

potentially hazardous effects of all substances you work with. Always observe

Good Laboratory Practice (GLP) guidelines, published by the U.S. Food and

Drug Administration, and consult your organization’s safety representative

for guidance.

When you develop methods, follow the “Protocol for the Adoption of Analytical

Methods in the Clinical Chemistry Laboratory,” American Journal of Medical

Technology, 44, 1, pages 30–37 (1978). This protocol addresses good operating

procedures and the techniques necessary to validate system and method

performance.

Instrument-specific safety considerations

Solvent leakage hazard

The source exhaust system is designed to be robust and leak-tight. Waters

recommends you perform a hazard analysis, assuming a maximum leak into

the laboratory atmosphere of 10% HPLC eluate.

Warning:

• To confirm the integrity of the source exhaust system, the

source seals must be renewed at intervals not exceeding one

year.

• The source seals can withstand exposure only to specific

solvents, see Appendix C in the Waters TQ Detector Operator’s

Guide. If you intend to use solvents other than those listed,

you must first determine whether those solvents are

compatible with the composition of the seals.

Flammable solvents hazard

Never let the nitrogen supply pressure fall below 400 kPa (4 bar, 58 psi)

during analyses that require flammable solvents. Connect to the LC output

with a gas-fail connector to stop the LC solvent if the nitrogen supply fails.

High temperature hazard

Waters TQ Detector high temperature hazard:

Warning: Where significant quantities of flammable solvents are

involved, the source must receive a continuous flow of nitrogen to

prevent possible ignition within that enclosed space.

Warning: The source enclosure can be hot. To avoid burn injuries,

avoid touching the source enclosure when operating or servicing the

TQ Detector.

Source enclosure assembly

High voltage hazard

Safety advisories

Consult Appendix A for a comprehensive list of warning and caution

advisories.

Warning:

• To avoid electric shock, do not remove the TQ Detector’s protective

panels. The components they cover are not user-serviceable.

• To avoid non-lethal electric shock, any equipment connected to the

ESI and IonSABRE™ APCI probes must be grounded.

• When the TQ Detector is in Operate mode, certain external surfaces

can conduct high voltages. To avoid non-lethal electric shock, make

sure the instrument is in Standby mode before touching areas

marked with this high voltage warning symbol.

vii

Operating this device

When operating this device, follow standard quality control procedures and

the guidelines presented in this section.

Symbols

Intended use

The Waters Tandem Quadrupole (TQ) Detector is intended to be used as a

research tool to deliver authenticated mass measurement in both MS and

MS/MS modes.

The Waters TQ Detector can be used for general In Vitro Diagnostic

applications, only by professionally trained and qualified laboratory

personnel.

Symbol Definition

Authorized Representative of the

European Community

The CE symbol serves as

confirmation of the conformity of a

product with all European

Community directives applicable to

that product.

For in vitro diagnostic use.

The Waters TQ Detector is CE-marked according to the

European Union In Vitro Diagnostic Device Directive 98/79/EC.

EC REP

IVD

viii

Calibration

To calibrate LC systems, follow acceptable calibration methods using at least

five standards to generate a standard curve. The concentration range for

standards should cover the entire range of quality-control samples, typical

specimens, and atypical specimens.

To calibrate mass spectrometers, consult the calibration section of the

operator’s guide of the instrument you are calibrating.

Quality control

Routinely run three quality-control samples that represent subnormal,

normal, and above-normal levels of a compound. Ensure that quality-control

sample results fall within an acceptable range, and evaluate precision from

day to day and run to run. Data collected when quality control samples are out

of range might not be valid. Do not report these data until you are certain that

the instrument performs satisfactorily.

When analyzing samples from a complex matrix such as soil, tissue,

serum/plasma, whole blood, etc., note that the matrix components can

adversely affect LC/MS results, enhancing or suppressing ionization. To

minimize these matrix effects, Waters recommends you adopt the following

measures:

• Prior to the instrumental analysis, use appropriate sample

pretreatment such as protein precipitation, liquid/liquid extraction

(LLE), or solid phase extraction (SPE) to remove matrix interferences.

• Whenever possible, verify method accuracy and precision using

matrix-matched calibrators and QC samples.

• Use one or more internal standard compounds, preferably

isotopically-labeled analytes.

IVD authorized representative information

IVD authorized representative

Waters Corporation (Micromass UK Limited) is

registered in the United Kingdom with the

Medicines and Healthcare Products Regulatory

Agency (MHRA) at market Towers, 1 Nine Elms

Lane, London, SW8 5NQ. The reference number

is IVD000167.

Waters Corporation (Micromass UK Ltd.)

Floats Road

Wythenshawe

Manchester M23 9LZ

United Kingdom

Telephone: +44-161-946-2400

Fax: +44-161-946-2480

Contact: Quality manager

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